Mark L. Cannon, DDS, MS
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Research Publications


Research Publications
Research Publications
Dr. Cannon is a past president of the Illinois Society of Dentistry for Children, and a member of the International Association of Pediatric Dentistry. In addition to maintaining a large private practice in the suburbs of Chicago, he has lectured at many national and international meetings, often as the keynote speaker. He has presented to a large number of state and local dental societies. Dr. Cannon is a guest lecturer at Sao Paulista State University, UNESP, in Aracatuba, Brazil, and at the University of Illinois, Chicago, Department of Pediatric Dentistry.

Dr. Cannon has presented research publications to the following organizations; I.A.D.R./A.A.D.R., the American Academy of Pediatric Dentistry, the American Society of Dentistry for Children, Academy of Dental Materials, World Congress of Biological Materials, International Association of Pediatric Dentistry, Pediatric Dental Association of Asia, Australasian Academy of Pediatric Dentistry, World Congress of Preventive Dentistry, Korean Academy of Pediatric Dentistry, Mexican Academy of Pediatric Dentistry and the European Academy of Pediatric Dentistry.

Scholarly Bibliography

​
Cannon, M. L.,                    
An In Vivo and In Vitro Study of the Surface Resistance to Abrasion of Performed Laminate Resin Veneer; Master’sThesis, Northwestern University, Chicago, Illinois, 1980
​

A. Referred Journals:
Moyer I. N                    
Kobayashi R. H.,  Rich K.,.Cannon, M. L., Simon J. F., Cooley R. O., Rich K. Dental Treatment of Children with Severe Combined Immunodeficiency; Pediatric Dentistry; Vol. 5, no. 1: 79 - 82, 1983
Cannon, M. L.,                   
Marshall G. W., Marshall S. J., Cooley R. O. Surface Resistance to Abrasion of Preformed Laminate Resin Veneers; Journal of Prosthetic Dentistry; 

Vol. 52, No. 3; 323 - 330, 1984
Cannon, M. L.,                   
Esquilin M., Cooley R. O. Microleakage of Two Flowable Composites Placed After Microabrasion Preparation; Hellenic Dental Journal 7:39-4, 1997.
Cannon, M. L.,                   
Tylka J, A., Sandrik J. Adhesive Amalgams in Pediatric Dental Practice, Compendium, April, 1999.
Cannon, M. L.,                   
A Clinical Study of the “Open Sandwich” Technique, Journal of Dentistry for Children, June, 66 -70, 2003.
Cannon, M. L.,                   
Advances in Pediatric Esthetic Dentistry, Vol. 24, No. 7, 39-44, Compendium, July 2003.
Kannon C. M.                
de Oliveira J. A., Cannon M. L., Carvalho A., The mandibular lingula’s position in children as a reference to inferior alveolar nerve block, Journal of Dentistry for Children , May-Aug 2005.
Silva K. G.                
Pedrino D., Delbem A.,., Cannon M L., Effect of pH Variations in a Cycling model on the Properties of Restorative Materials, Journal of Operative Dentistry, 32-4, 328-335, July/August 2007.
Silva K. G.                
Pedrino D., Delbem A., Cannon M. L. Microhardness and Fluoride Release of Restorative Materials in Different Storage Media, Braz Dent J (2007).
Cannon M. L.,               
Sealant Materials and Applications- Interview, ADA Newsletter, JADA, February 2008.
Gomes-filho, JE.           
Dougals de Faria, M., Bernabe P., Nery M., Otoboni-filho J., Dezan-Junior E., Costa M., Cannon M., Mineral Trioxide Aggregate but not Light Cured Mineral Trioxide Aggregate Stimulated Mineralization . J of Endo, 2008.
Cannon M. L.,           
Cernigliaro J, Vieira A. E., Percinoto C., Jurado R. Effects Of Antibacterial Agents On Dental Pulps Of Monkeys Mechanically Exposed And Contaminated. J of Clinical Pediatric Dentistry, Vol 33 p21-28, August, 2008.
Stock S. R.          
Vieira AE, Delbem AC, Cannon ML, Xiao X, Carlo FD. Synchrotron microComputed Tomography of the mature bovine dentinoenamel junction. J Struct Biol. 2008 Feb;161(2):162-71. Epub 2007 Oct 23.
Delbem A. C.         
Sassaki KT, Vieira AE, Rodrigues E, Bergamaschi M, Stock SR, Cannon ML, Xiao X, De Carlo F. Comparison of methods for evaluating mineral loss: hardness versus synchrotron microcomputed tomography. Caries Res. 2009;43(5):359-65. doi: 10.1159/000231573. Epub 2009 Aug 1.
Silva K. G.        
Pedrino D., Delbem A., Ferreia L., Cannon M. In Situ Evaluation of Pit and Fissure Sealants Containing Amorphous Calcium Phosphate And/or Fluoride Acta Odontologica Scandinavica, 2010; 68: 11–18.
Gomes-Filho J. E.       
de Moraes Costa MT, Cintra LT, Lodi CS, Duarte PC, Okamoto R, Bernabé PF, Nery MJ, Cannon M. Evaluation of alveolar socket response to Angelus MTA and experimental light-cure MTA. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Nov;110(5):e93-7. doi: 10.1016/j.tripleo.2010.05.065. Epub 2010 Sep 27.
Cannon, M. L.     
Wagner C. Thobaben J., Jurado R., Solt D. Early Response of Mechanically Exposed Dental Pulps of Swine to Anti-bacterial-Hemostatic Agents or Diode Laser Irradiation, J Clin Pediatric Dent 35(3):269-274, 2011.
Cannon, M.     
A Review of Probiotic Therapy in Preventive Dental Practice, Probiotics and Anti-microbial Proteins, Vol 3, Num 2,  July 2011.
Ferreira L.
Pedrini D, Okamoto AC, Jardim Júnior EG, Henriques TA, Cannon M, Delbem AC. Biochemical and microbiological characteristics of in situ biofilm formed on materials containing fluoride or amorphous calcium phosphate. Am J Dent. 2013 Aug;26(4):207-13.
Cannon M. L.
Trent B, Vorachek A, Kramer S, Esterly R. Effectiveness of CRT at measuring the salivary level of bacteria in caries prone children with probiotic therapy. J Clin Pediatr Dent. 2013 Fall;38(1):55-60.
Cannon M. L.
Gerodias N., Vieira A., Percinoto C., Jurado R. Primate Pulpal Healing after Exposure and TheraCal Application. J Clin Pediatr Dent. 2014 38(4):291-295.
Delbem A. E.
In vitro effect of amorphous calcium phosphate paste applied for extended periods of time on enamel remineralization J of Oper Dent Jan 2015.
​
Vieira, A. E. de M., 
Danelon, M., da Camara, D. M., Rosselli, E. R., Stock, S. R., Cannon, M. L., … Delbem, A. C. B. (2017). In vitro effect of amorphous calcium phosphate paste applied for extended periods of time on enamel remineralization. Journal of Applied Oral Science, 25(6), 596–603. http://doi.org/10.1590/1678-7757-2016-0513. 

Ferrer G.  
Cannon ML., Nasal Irrigation, Polyols, Nitrate Reducing Bacteria and Cardiovascular Disease. Exp Rhinol Otolaryngol, Sept 2017. 

Cannon M. L.
Peldyak J., The Prevention and Treatment of Neural Arterial Gingival Simplex. Volume 3 Issue 1 | PDF 123 | Page 6 Dental Research and Management https://doi.org/10.33805/2572-6978.123

Cannon M. L.
Vorachek A., Le C., White K. Retrospective Review of Oral Probiotic Therapy. Journal of Clinical Pediatric Dentistry. Volume 43, Number 6/2019 43(6), 367–371. https://doi.org/10.17796/1053-4625-43.6.1

Cannon M. L.
Kabat B., Yogev R., Jantra L., Awan A., Le C., White K. and Vorachek A. Inhibition of Rothia Species by Over-the-Counter Products and Bacterial Antagonists. Edelweiss Applied Science and Technology Volume 4 Issue 1 | PDF 173 | Pages 4 https://doi.org/10.33805/2576-8484.173

Cannon M. L.
Peldyak J., Pediatric Oral Systemic Health: From Fetus to Adolescence. Interventions in Pediatric Dentistry Open Access Journal. DOI: 10.32474/IPDOAJ.2019.03.000158

Cannon M. L.
Kabat B., Yogev R., Awan A., Jantra L. and Vorachek A. Investigation into Gluten Metabolizing Bacterial Species and their Inhibition. Edelweiss Journal of Biomedical Research and Review. Volume 2 Issue 1 | PDF 107 | Pages 4 https://doi.org/10.33805/2690-2613.107

Cannon M. L.
Merchant M Kabat W  Le Catherine  White K Unruh B Ramones A. In Vitro Studies of Xylitol and Erythritol Inhibition of Streptococcus. The Journal of Clinical Pediatric Dentistry Volume 44, Number 5/2020 doi 10.17796/1053-4625-44.5.4

Gonçalves F.M.C. 
Delbem ACB, Gomes LF, Emerenciano NG, Dos Passos Silva M, Cannon ML, Danelon M. Combined effect of casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate on the prevention of enamel demineralization and dental caries: an in vitro study. Clin Oral Investig. 2020 Sep 30. doi: 10.1007/s00784-020-03597-7. Online ahead of print. PMID: 32995976

Gonçalves F.M.C. 
Delbem ACB, Gomes LF, Emerenciano NG, Pessan JP, Romero DGA, Cannon ML, Danelon M. Effect of fluoride, casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate combination treatment on the remineralization of caries lesions: An in vitro study Archives of Oral Biology 122 (2021) 105001. https://doi.org/10.1016/j.archoralbio.2020.105001)

Cannon M. L. 
Peldyak J. The Essential Role of Xylitol. Inside Dentistry April 2021. CDEworld.

Marcato, R. A.
Garbelini, C. C. D., Danelon, M., Pessan, J. P., Emerenciano, N. G., Ishikawa, A. D. S., Cannon M., Delbem, A. C. B. In situ evaluation of 200 ppm fluoride toothpaste content trimetaphosphate, xylitol and erythritol on enamel demineralization and dental biofilm.. J Dent, 111 2021 Aug;111:103724. doi: 10.1016/j.jdent.2021.103724. Epub 2021 Jun 9.

Cannon M. L. 
Duchaj S., Patel R., Kabat B. Temporal Exposure of Dermal Fibroblasts to Silver Diamine Fluoride and Fluorine NMR Quantitation J Clin Pediatr Dent (2022) 45 (6): 395–405.DOI: https://doi.org/10.17796/1053-4625-45.6.6 Published: 07 January 2022

de Toledo, P. T. A.
Delbem, A. C. B., Cannon, M. L., Sakamoto, A. E.,  Pedrini, D. . The effect of toothpaste with reduced concentration of fluoride-containing sodium trimetaphosphate and polyols on initial enamel erosion. Clinical Oral Investigations, 26(12), 7243–7252. https://doi.org/10.1007/s00784-022-04684-7 2022

Oliveira, L. G.
Delbem, A. C. B., Gonçalves, F. M. C., Fernandes, G. L. P., Cannon, M. L., & Danelon, M. (2023). In vitro effect of low-fluoride toothpaste supplemented with sodium trimetaphosphate, xylitol, and erythritol on enamel demineralization. Journal of applied oral science : revista FOB, 31, e20220410. https://doi.org/10.1590/1678-7757-2022-0410

de Toledo, P. T. A., 
Delbem, A. C. B., Cannon, M. L., Sakamoto, A. E., & Pedrini, D. (2022). The effect of toothpaste with reduced concentration of fluoride-containing sodium trimetaphosphate and polyols on initial enamel erosion. Clinical oral investigations, 26(12), 7243–7252. https://doi.org/10.1007/s00784-022-04684-7

Díaz-Fabregat, B., 
Ramírez-Carmona, W., Cannon, M. L., Monteiro, D. R., Pessan, J. P., & Antoniali, C. (2024). Are salivary NO2- / NO2- and NO3- levels biomarkers for dental caries in children? Systematic review and meta-analysis. Nitric oxide : biology and chemistry, 144, 11–19. https://doi.org/10.1016/j.niox.2024.01.001

Oliveira, M. A. F., 
Gonçalves, F. M. C., Delbem, A. C. B., Fernandes, G. L. P., Cannon, M. L., & Danelon, M. (2024). Effect of treatment with phosphate, casein phosphopeptide and fluoride on the remineralization: in vitro study. Brazilian oral research, 38, e036. https://doi.org/10.1590/1807-3107bor-2024.vol38.0036

Gonçalves, F. M. C.  
de Almeida, E. M. F. C., Hannig, C., Quinteiro, J. P., Delbem, A. C. B., Cannon, M. L., & Danelon, M. (2024). Biofilm modulation and demineralization reduction after treatment with a new toothpaste formulation containing fluoride, casein phosphopeptide-amorphous calcium phosphate, and sodium trimetaphosphate: In situ study. Dental materials : official publication of the Academy of Dental Materials, S0109-5641(24)00289-6. Advance online publication. https://doi.org/10.1016/j.dental.2024.09.018

Cannon, M., 
Toma, R., Ganeshan, S., de Jesus Alvarez Varela, E., Vuyisich, M., & Banavar, G. (2024). Salivary Transcriptome and Mitochondrial Analysis of Autism Spectrum Disorder Children Compared to Healthy Controls. NeuroSci, 5(3), 276–290. https://doi.org/10.3390/neurosci5030022

Cannon, M., 
Ferrer, G., Tesch, M., & Schipma, M. (2024). Whole-Genome Deep Sequencing of the Healthy Adult Nasal Microbiome. Microorganisms, 12(7), 1407. https://doi.org/10.3390/microorganisms12071407

Oliveira, M. 
A. F., Gonçalves, F. M. C., Delbem, A. C. B., Fernandes, G. L. P., Cannon, M. L., & Danelon, M. (2024). Effect of treatment with phosphate, casein phosphopeptide and fluoride on the remineralization: in vitro study. Brazilian oral research, 38, e036. https://doi.org/10.1590/1807-3107bor-2024.vol38.0036

Cannon, M.
The Fundamentals of Maternal Oral Health and Pregnancy Onset Sleep Apnea, Journal of the American Orthodontic Society 2024.

Cannon, M.
Quinteiro, J. P., Hannig, C., de Almeida, E. M. F. C., Delbem, A. C. B., Cannon, M. L., & Danelon, M. (2025). In situ remineralization of enamel caries lesions with a toothpaste supplemented with fluoride, amorphous calcium phosphate casein phosphopeptide and trimetaphosphate. Journal of dentistry, 155, 105618. https://doi.org/10.1016/j.jdent.2025.105618

Cannon, M.
Cosantino, A., Tran, L., Chandel, N. S., & Ghoreishi, N. (2025). Effects of Xylitol on Tumor Progression in Syngeneic Mice Cancer Models. Nutraceuticals, 5(1), 4. https://doi.org/10.3390/nutraceuticals5010004

Cannon, M.,  
Dempsey, E., Cosantino, A., & Ghoreishi, N. (2025). Analysis of Osmotic Pump-Administered Xylitol in a Syngeneic Mouse Melanoma Model. Nutraceuticals, 5(4), 36. https://doi.org/10.3390/nutraceuticals5040036

Cannon, M.,  
Baghaie, S., Guzman, L., Cosantino, A., & Maurer, B. (2025). Whole Genome Deep Sequencing of the Oral Microbiome in Epidermolysis Bullosa. Dermato, 5(3), 17. https://doi.org/10.3390/dermato5030017

Cannon, M.,  
Stevenson, B. S. (2026). In Vitro Inhibition of Pathogens by Polyols: Optical Density-Based Screening and Implications for the Oral-Systemic Axis. Microorganisms, 14(4), 884. https://doi.org/10.3390/microorganisms14040884

Cannon, M.,  
Peldyak, J., & Reynolds, P. (2026). Micro/Nanoplastics and Periodontitis: An Environmental Microbiology Perspective on Oral Retention and Systemic Risk. Microorganisms, 14(5), 1014. https://doi.org/10.3390/microorganisms14051014

Cannon, M.,  
Peldyak, J. Xylitol, Mitochondrial Plasticity, the Warburg Effect, and Oral Pathobiont-Associated Immune Evasion in Cancer Hypothesis. Int. J. Mol. Sci. 2026, 27, 6130. https://doi.org/10.3390/ijms27146130

Cannon, M.,  
Peldyak, J., & Campbell, E. (2026). The Liver as the Central Regulator of Cholesterol Homeostasis: Statins, Gut Microbiota, Hepatic Inflammation, and the Proposed Oral–Gut–Liver–Artery Axis in Atherogenesis. Metabolites, 16(7), 495. https://doi.org/10.3390/metabo16070495

Cannon, M.,  
Peldyak, J., Reynolds, P. R., & Bikman, B. (2026). Cyclic Altitude Training, Mitochondrial Health, and the Oral–Airway Axis: Intermittent Hypoxia Between Adaptation and Disease. Journal of Clinical Medicine, 15(14), 5402. https://doi.org/10.3390/jcm15145402

B. Editorials, Chapters, Books:

Cannon M. L.
Cannon M. L., Resin Based Composites, Wileys Encyclopedia of Medical Devices and Instruments, 2004.

C. Case Reports:

Cannon M. L.
Cooley R. O., Gonzalez- Crussi F., Labokta R. The Oral Manifestations of Malignant Histiocytosis; Oral Surgery, Oral Medicine; Oral Pathology 54:180 - 185, 1982
Cannon M. L.
​
Spiegel R. E., Cooley R. O. Cherubism: Report of Case; Journal of Dentistry for Children; July - August, 292 - 295, 1983.

D. Clinical Articles:

Cannon M. L.,
Early Childhood Caries; Taking treatment out of the Hospital, Dentistry Today, February, 2007.
Cannon M. L.,
A New Therapeutic Pit and Fissure Sealant Improves Early Dental Caries Monitoring for Minimally Invasive Dentistry. Inside Dentistry, May 2008.
Cannon M. L.,
Amorphous Calcium Phosphate Sealants. Inside Dentistry, p86-89, February 2010.
Cannon M. L.,
Clinical Application of Probiotic Therapy, Inside Dentistry, 2011; June, 112-113.
Cannon M. L.,
Application of a light-cured Pulp-Capping Material: An Adjunct to the Practice of Minimally Invasive Dentistry. Journal of Dent Research and Applications, Vol 1, Number 1,p58-63. Nov-Dec, 2007. ( Journal ceased publication first year, but claimed to be peer reviewed).
Cannon M. L.,
Comisi JC. Bioactive and therapeutic preventive approach to dental pit and fissure sealants. Compend Contin Educ Dent. 2013 Sep;34(8):642-5.
Cannon M. L.,
Childs P., Pulp capping: Improving the Prognosis, DentalTown Jan 2015.
​
​
​Cannon M. L., 
Bioactive Material Considerations for Vital Pulp-Capping Protocols, CDE January 2017 Vol. 4 N67. (updated 8/18)

​
Cannon M. L., 
Treating Dental Trauma. Inside Dentistry, June 2017. (updated 8/18)

Cannon M. L., 
First, Do No Harm. Inside Dentistry, November 2017. (updated 8/18)

Cannon M. L., 
How to achieve esthetic restorations for the pediatric dental patient. Dental Products Review, December 2017. (updated 8/18)

Cannon M. L., 
How to use cavity liners to provide better care. Dental Products Review. April 2018.

Cannon M. L., 
Pulp Therapy in the Difficult Child Patient. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 40(suppl 1), 20–22. 2019.

Cannon M. L.
The Routine Use of Incompatible Dental Materials in Dentistry - Why? Dental Learning. May 2021.

Cannon M. L.
Dentistry of the Future- The Profitable Dentist, 2023.

Cannon M. L. 
Pregnancy Induced Sleep Apnea and its consequences - The Profitable Dentist, 2024.




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